载脂蛋白E4 与阿尔茨海默病关联性研究进展

doi:10.3969/j.issn.2095-1396.2016.06. 003

摘要/Abstract

摘要： 阿尔茨海默病（Alzheimer’s disease，AD）是一种常见的神经退行性疾病，致病机理复杂且尚未明了。近几十年发现，载脂蛋白E（apolipoprotein E，ApoE）参与该病的发生、发展进程。ApoE 是脂质转运代谢中重要的蛋白，三种亚型（ApoE2，ApoE3 和ApoE4）中，ApoE4 与AD 的各个病程更是密切相关。因此，该文对ApoE4的生物化学特点及与AD 相关的Aβ、tau 蛋白、突触的可塑性、神经毒性和炎症反应的关联性进行综述，以便后续研究参考。

关键词: 载脂蛋白E4, 阿尔茨海默病, &, beta, 淀粉样蛋白, 治疗靶点

Abstract: Alzheimer’s disease（AD） is a progressive neurodegenerative disorder， but the pathogenesis of AD is still complicated and indeterminate. In recent decades， evidence indicates that apolipoprotein E4（ApoE4） is a multifunctional protein with central roles in lipid metabolism which also plays an important role in AD. Here we review recent progress on the relationship between ApoE4 and AD.

Key words: apolipoprotein E4, Alzheimer&, rsquo, s disease, &, beta, -amyloid protein, treatment target

高金超, 赵文娟, 殷明. 载脂蛋白E4 与阿尔茨海默病关联性研究进展[J]. 神经药理学报, 2016, 6(6): 31-39.

GAO Jin-chao, ZHAO Wen-juan, YIN Ming. Progress in the Relationship of Apolipoprotein E4 on Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(6): 31-39.

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